Integrated ligand-receptor bioinformatic and in vitro functional analysis identifies active TGFA/EGFR signaling loop in papillary thyroid carcinomas.

BACKGROUND: Papillary thyroid carcinoma (PTCs), the most frequent thyroid cancer, is usually not life threatening, but may recur or progress to aggressive forms resistant to conventional therapies.A more detailed understanding of the signaling pathways activated in PTCs may help to identify novel therapeutic approaches against these tumors.The aim

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Beyond the basics: a perspective on barriers and opportunities for scaling up biochar production from forest slash

Abstract Biochar production from woody biomass generated during forest management (slash) offers significant benefits for soil health and carbon emissions, yet its adoption remains limited in the western United States (U.S.).To address this challenge, the U.S.Department of Agriculture (U.S.D.A.) Forest Service Rocky Mountain Research Station organi

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The Italian Democratic Party, its nature and its Secretary

The Democratic Party (PD) is the only reasonably organized party in the Italian de-structured party system.It is itself undergoing a process of transformation.It defies all traditional party definitions.It is no longer a class-based mass party and not even a mass party.Nobody within the party believes Magnesium that such a party can resurrect.It sh

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